DEFINITY® News and Updates

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We are committed to the professional and patient communities we serve. In the spirit of this commitment, we invite ongoing feedback and dialogue.

Corporate Information:
331 Treble Cove Rd.
N. Billerica, MA 01862
Call Toll-Free: 1.800.362.26681.800.362.2668

US Customer Service/Order DEFINITY®:
Monday-Friday 7:30 AM to 6:00 PM ET
Call Toll-Free: 1.800.299.34311.800.299.3431
Fax: 1.978.671.8860
Fax Orders/POs: 1.978.436.7501

DEFINITY® Reimbursement Support:

Call Toll-Free: 1.800.362.26681.800.362.2668 
Press Option 3 for Reimbursement Regarding DEFINITY® 

Lantheus cannot guarantee coverage or payment for products or procedures. Payer policies can vary widely and third-party payment for medical products and services is affected by numerous factors. It is always the provider's responsibility to determine and submit appropriate codes, charges, and modifiers for services rendered. For more specific information, contact your third-party payer directly in order to obtain up-to-date coverage, coding, and payment information.

Adverse Event and Product Quality Complaint Reports:

United States:
Call Toll-Free: 1.800.343.78511.800.343.7851
Press Option 2 for Adverse Events
Press Option 2 for Product Quality Complaints
Fax: 1.978.436.7296

Outside the US:
Call Toll-Free: 1.978.667.95311.978.667.9531
Press Option 2 for Adverse Events
Press Option 2 for Product Quality Complaints
Fax: 1.978.436.7296


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DEFINITY® is indicated, after activation, for use in adult and pediatric patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border.



Serious cardiopulmonary reactions, including fatalities, have occurred uncommonly during or following perflutren-containing microsphere administration. Most serious reactions occur within 30 minutes of administration.

  • Assess all patients for the presence of any condition that precludes DEFINITY® administration [see Contraindications (4)].
  • Always have resuscitation equipment and trained personnel readily available [see Warnings and Precautions (5.1)].